Abstract
THE carcinogenic activity of polycyclic hydrocarbons administered subcutaneously to hamsters was first described by Gye and Foulds1. Later, Halberstaedter2, Crabb3, and Lutz et al.4 reported the sarcomagenic activity of other polycyclic hydrocarbons in hamsters. These investigators were primarily interested in the question of transplantability and metastases and used multiple injections for tumour production.
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References
Gye, W. E., and Foulds, L., Amer. J. Cancer, 35, 108 (1939).
Halberstaedter, L., Amer. J. Cancer, 38, 351 (1940).
Crabb, E. D., Cancer Res., 6, 627 (1946).
Lutz, B. R., Fulton, G. P., Patt, D. I., Handler, A. H., and Stevens, D. F., Cancer Res., 11, 64 (1951).
Iball, J., Amer. J. Cancer, 35, 188 (1939).
Shimkin, M. B., and Andervont, H. B., J. Nat. Cancer Inst., 1, 57 (1940).
Leiter, J., and Shear, M. J., J. Nat. Cancer Inst., 3, 445 (1943).
Kelly, M., and O'Gara, R. W., Nature, 196, 1220 (1962).
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WODINSKY, I., HELINSKI, A. & KENSLER, C. Susceptibility of Syrian Hamsters to Induction of Fibrosarcomas with a Single Injection of 3,4,9,10-Dibenzpyrene. Nature 203, 308–309 (1964). https://doi.org/10.1038/203308a0
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DOI: https://doi.org/10.1038/203308a0
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