Abstract
WE have recently obtained information from work on normal subjects and mild and severe diabetics indicating that insulin has an increasing effect on hepatic glucose metabolism in untreated diabetics with progressively elevated fasting blood sugar-levels and glycosuria implying greater degrees of catabolism and gluconeogenesis1. There is also evidence of a hepatic action of insulin when diabetic patients are treated with phenethylbiguanide2. In view of the similarity between the ethylbiguanide side-chain and the nucleotides adenine and guanine, we wished to test the effect of these compounds on hepatic carbohydrate metabolism and on the action of insulin on the liver.
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Kaldor, A., and Pogatsa, G., Diabetes, 2, Supp. 16 (1962).
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KALDOR, A., RIHAN, Z., NICHOLS, T. et al. Effects of Adenine and Guanine on Hepatic Glucose Release and on the Action of Insulin on the Liver. Nature 203, 1186 (1964). https://doi.org/10.1038/2031186a0
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DOI: https://doi.org/10.1038/2031186a0
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