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Occurrence of Homoserine in the Liver of Ethionine- or Methionine-treated Rats

Nature volume 203, pages 1177–1178 (1964)Cite this article

Abstract

INTRAPERITONEAL administration of L-methionine1 as well as incorporation of DL-methionine2 and DL-ethionine3 in the purified diets of rats resulted in increased activity of rat liver cystathionase (‘soluble’ cysteine desulphydrase). Recently, I have also observed4 that one injection of L-ethionine likewise caused, in 4 h, significant increase in the activity of the enzyme in rat liver. In an effort to determine the chemical basis for the effects of these amino-acids, analyses of the free amino-acids of the liver of control (non-treated) as well as of ethionine and methionine-treated rats were carried out.

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Authors and Affiliations

  1. Laboratoire de Chimie Biologique, 96 boulevard Raspail, Paris

    FERNANDE CHATAGNER

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  1. FERNANDE CHATAGNER
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CHATAGNER, F. Occurrence of Homoserine in the Liver of Ethionine- or Methionine-treated Rats. Nature 203, 1177–1178 (1964). https://doi.org/10.1038/2031177b0

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