Abstract
THE selective localization of tetracyclines in mineralizing tissues has prompted consideration of possible untoward skeletal effects associated with their use in medical practice. Commanding attention in this respect are investigations in human beings showing that exposure to these antibiotics during tooth formation produces hypoplasia of the dental enamel1–5. It has also been reported that tetracycline can interfere with the growth of the long bones in infants6,7. Moreover, there is evidence that these agents can impair fracture healing in dogs8 and can adversely affect mineralization in a wide range of animal forms including the larval sand dollar9, a teleost fish10, the chick embryo11, a marine mollusc12 and the rat13,14.
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LIKINS, R., PAKIS, G. Bone Growth and Uptake of Radiocalcium in Tetracycline-treated Rats. Nature 203, 1069–1070 (1964). https://doi.org/10.1038/2031069a0
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DOI: https://doi.org/10.1038/2031069a0
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