Abstract
Vaichulis and Doll1 have shown that the true susceptibility of Mycobacterium tuberculosis to penicillin was never validly determined. Recent experiments2 have shown that penicillin is bactericidal for and acts synergistically with isoniazid against isoniazid sensitive and resistant M. tuberculosis. Utilizing the Warburg technique to examine the mode of action of penicillin on Mycobacteria we have found that penicillin inhibits the endogenous respiration of Mycobacterium smegmatis and that penicillin potentiates the inhibitory action of isoniazid.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Vaichulis, E. M. K., and Doll, J. P., Amer. Rev. Resp. Dis., 80, 262 (1959).
Vaichulis, E. M. K., Vicher, E. E., and Novak, M. V., Amer. Rev. Resp. Dis., 86, 744 (1962); also in preparation.
Vaichulis, E. M. K., Amer. Rev. Resp. Dis., 83, 121 (1961).
Bernheim, F., J. Biol. Chem., 143, 383 (1942).
Nasta, M., Paunesco, E., and Georgesco, P., Ann. Inst. Pasteur, 99, 504 (1960).
Pope, H., Amer. Rev. Pulmonary Dis., 73, 735 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
VAICHULIS, E., VICHER, E. & NOVAK, M. Inhibition of the Endogenous Metabolism of Mycobacterium smegmatis by Penicillin and Isoniazid. Nature 202, 726–727 (1964). https://doi.org/10.1038/202726a0
Issue Date:
DOI: https://doi.org/10.1038/202726a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
