Abstract
THE cells responsible for the immune response vary in susceptibility to inhibitory agents at different stages of the response. Radiation and busulphan (‘Myleran’) inhibit the response to the greatest degree if administered before the antigen and are relatively ineffective if given afterwards1,2. Alkylating agents other than busulphan (the mustards and ethylene imines) and the antimetabolites are most effective if given some 1–3 days after the antigen and are less effective if given beforehand2,3.
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BROWN, I., BERENBAUM, M. Inhibition of Immune Processes by ‘Melphalan’. Nature 201, 1340 (1964). https://doi.org/10.1038/2011340a0
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DOI: https://doi.org/10.1038/2011340a0
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