Abstract
A TERATOGENIC agent is one which, acting directly or indirectly on the developing organism, alters ontogenesis with consequent production of a malformed individual. In order to produce its characteristic effects the agent must be given within a specific dosage range, but this aspect of teratology is often neglected. Attempts have been made1,2 to compare the teratogenic dose of certain substances with the adult LD50 and recently the fœtal LD50 has been considered useful3. This has led workers to relate embryo-toxic doses of drugs with their therapeutic dose4, and regression lines relating fœtal resorption to dose have been constructed for a number of drugs5. Here, dosage–response curves for the teratogenic dye trypan blue are constructed, and certain parameters relevant to teratogenic activity defined; these definitions may be widely applicable6.
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BECK, F., LLOYD, J. Dosage – Response Curves for the Teratogenic Activity of Trypan Blue. Nature 201, 1136–1137 (1964). https://doi.org/10.1038/2011136b0
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DOI: https://doi.org/10.1038/2011136b0
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