Rates of Acid Hydrolysis of 2-substituted Methyl Glucopyranosides

Abstract

THE hydrolysis of methyl glycosides probably proceeds through the formation of an oxonium salt as intermediate1–3. The steps involved in the reaction of water with a methyl glycoside may thus be represented: where k3 represents the rate constant for what is generally believed to be the rate-controlling step.

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MARSHALL, R. Rates of Acid Hydrolysis of 2-substituted Methyl Glucopyranosides. Nature 199, 998–999 (1963). https://doi.org/10.1038/199998b0

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