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Influence of Bacillus Calmette-Guérin Infection on the Intensity of Homograft Reaction in Rats

Naturevolume 199pages507508 (1963) | Download Citation



IN order to investigate the non-specific stimulation of the reticulo-endothelial system and consequences of this stimulation on the intensity of specific immune reactions it was decided to find out whether bacillus Calmette-Guérin (B.C.G.) infection would influence the rate and intensity of homograft reaction. Results have already shown1 that the first set homograft rejection was markedly accelerated in B.C.G. infected rats. A similar effect was described by Balner, Old and Clarke2. They observed an accelerated skin graft rejection in B.C.G. infected female C57BL/6 mice grafted with isologous male skin.

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  1. 1

    Vitale, B., and Allegretti, N., Abstr. Comm., Second Yugoslav Cong. Biol., Belgrade, 125 (1962).

  2. 2

    Balner, H., Old, L. J., and Clarke, D. A., Proc. Soc. Exp. Biol. and Med., 109, 58 (1962).

  3. 3

    Bailey, D. W., and Usama, B., Transplant. Bull., 7, 429 (1960).

  4. 4

    Berrian, J. H., and McKhann, C. F., Ann. N.Y. Acad. Sci., 87, 106 (1960).

  5. 5

    Zaalberg, O. B., Biological Problems of Grafting, 306 (Université de Liège, 1959).

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  1. Department of Biology, ‘Ruder Bošković’ Institute, Zagreb, Yugoslavia

    • B. VITALE
    •  & N. ALLEGRETTI


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