Letter | Published:

Microbiological Dehydroxylation of Cholic Acid



THE transformation of steroids by micro-organisms has been extensively applied to the steroid hormones and their derivatives1. More recently this technique has been extended to other compounds2. However, the dehydroxylation reaction of steroids by micro-organisms has not been reported.

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  1. 1

    Stoudt, T. H., Adv. App. Microbiol., 2, 183 (Academic Press, Inc., New York, 1960).

  2. 2

    Tamm, Ch., Angew. Chem., 74, 225 (1962). Sato, Y., and Hayakawa, S., J. Org. Chem., 26, 4181 (1961). Hayakawa, S., and Sato, Y., J. Org. Chem., 27, 704 (1962).

  3. 3

    Hayakawa, S., Fuji, T., Saburi, Y., and Eguchi, T., Nature, 179, 537 (1957). Hayakawa, S., Saburi, Y., Tamaki, K., and Hoshijima, H., Nature, 181, 906 (1958).

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