Letter | Published:

Nucleotide Sequence Investigations in Microsomal Ribonucleic Acids of Normal and Rous Sarcoma Virus-infected Tissues

Naturevolume 199pages488489 (1963) | Download Citation



A CHARACTERIZATION of nucleotide sequence in ribonucleic acids (RNAs) in tumours would be of importance to the understanding of the structure of these molecules in neoplastic tissues. Methods for the separation of mono-and oligo-nucleotides liberated with ribonuclease digestion by ion exchange chromatography have been developed1 and applied to amino-acid acceptor RNAs with promising results2. This communication describes an investigation of some nucleotide sequences in microsomal RNA extracts from normal and Rous sarcoma virus-infected tissues. These are initial studies of a programme designed to analyse the structure of the nuclear and cytoplasmic RNA's of normal and tumour cells.

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  1. Medical Research Center, Brookhaven National Laboratory, Upton, New York

    • N. DELIHAS
    •  & E. EVANS
  2. Sloan-Kettering Institute for Cancer Research, New York

    • N. DELIHAS
    •  & E. EVANS


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