Abstract
RECENT work1 has demonstrated that incubation of heart mitochondria with succinate, inorganic phosphate and NAD for short periods at 0° yields a highly labile mono-phosphorylated derivative of NADH. This derivative, capable of phosphorylating ADP, has the properties required for an oxidative phosphorylation intermediate and it is suggested that during its formation the nicotinamide ring has been opened1. (Abbreviations: NAD and NADH, oxidized and reduced nicotinamide adenine dinucleotide, respectively; ADP and ATP adenosine-5′-di- and tri-phosphate, respectively.)
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GAWRON, O. A Hypothesis linking the Succinic Dehydrogenase System to an Intermediate of Oxidative Phosphorylation. Nature 199, 377–378 (1963). https://doi.org/10.1038/199377a0
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DOI: https://doi.org/10.1038/199377a0
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