Abstract
THE induction of squamous carcinoma of the stomach and, of the oesophagus in the rat by N-nitroso-N-methyl-urethane (NMU)1 and by some other nitrosamines2 has been reported. Squamous tumours of the stomach have been known to develop following treatment with various other carcinogens; but very few instances have been reported of the induction of tumours of the glandular part of the stomach in rodents. Such tumours have usually been produced by direct intramural injection of carcinogenic polycyclic aromatic hydrocarbons3. One adenocarcinoma resulted after administration of 4-nitro-quinoline-N-oxide through a stomach fistula to 16 rats which had in addition percutaneous applications of 20-methylcholanthrene4. Recently, Stewart et al.5 induced adenocarcinomata of the glandular stomach in four out of 47 rats, given 2,7-bis(acetamido)fluorene in diet.
Similar content being viewed by others
Article PDF
References
Schoental, R., Nature, 188, 420 (1960). Schoental, R., and Magee, P. N., Brit. J. Cancer, 16, 92 (1962).
Druckrey, H., Preussmann, R., Schmähl, D., and Müller, M., Naturwiss., 48, 165 (1961). Druckrey, H., Preussmann, R., Blum, G., Ivankovic, S., and Afkham, J., Naturwiss., 50, 100 (1963).
Hare, W. V., Stewart, H. L., Bennett, J. G., and Lorenz, E., J. Nat. Cancer Inst., 12, 1019 (1952).
Baba, T., Misu, Y., and Takayama, S., Gann, 53, 381 (1962).
Stewart, H. L., Snell, K. G., Morris, H. P., Wagner, B. P., and Ray, F. E., Nat. Cancer Inst. Mon., 5, 105 (1961).
Schoental, R., Nature, 192, 670 (1961). Schoental, R., and Rive, D. J., Biochem. J., 87, 22, P (1963).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SCHOENTAL, R. Induction of Tumours of the Stomach in Rats and Mice by N-nitroso-N-alkylurethanes. Nature 199, 190 (1963). https://doi.org/10.1038/199190a0
Issue Date:
DOI: https://doi.org/10.1038/199190a0
This article is cited by
-
Erzeugung von Magen- und Pankreas-Krebs beim Meerschweinchen durch Methylnitroso-harnstoff und-urethan
Zeitschrift f�r Krebsforschung (1968)
-
Tumour Production in Glandular Stomach of Rat by N-Methyl-N′-Nitro-N-Nitrosoguanidine
Nature (1967)
-
Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso-Verbindungen an BD-Ratten
Zeitschrift f�r Krebsforschung (1967)
-
Carcinoma of the Glandular Stomach in Rats given Diets containing Aflatoxin
Nature (1966)
-
Carcinogenic Activity of N-Methyl-N-nitroso-N′-nitroguanidine
Nature (1966)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.