Abstract
THE total synthesis of β-corticotropin (ACTH), with the amino-acid sequence characteristic of the porcine species1 (Fig. 1), has been achieved2 using methods especially designed and developed for preparing large and complicated peptides3. They are: (a) formation of peptide bonds mainly by means of active esters4 (for example, p-nitrophenyl esters5,6); (b) protection of amino and carboxyl functions with such blocking groups derived from t-butanol that easily can be removed in the last stage of the synthesis without destruction of sensitive peptides3.
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SCHWYZER, R., SIEBER, P. Total Synthesis of Adrenocorticotrophic Hormone. Nature 199, 172–174 (1963). https://doi.org/10.1038/199172b0
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DOI: https://doi.org/10.1038/199172b0
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