Letter | Published:

Enhanced Suppression of the Secondary Immune Response by Combination of 6-Mercaptopurine ‘Duazomycin A

Nature volume 199, pages 11011102 (14 September 1963) | Download Citation

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Abstract

THE demonstration that 6-mercaptopurine (6-MP) is capable of inhibiting the immune response1,2 has aroused much interest and optimism concerning the therapeutic possibilities for organ transplantation and ‘auto-immune’ diseases. Extension of these studies has shown that immunological tolerance can be obtained by administration of 6-MP during the primary exposure to an antigen3. Although initial attempts to modify the secondary response to the antigen were unsuccessful4, a quantitative rather than qualitative effect seems to have been responsible, since proper timing and vigorous treatment with both antigen and drug will achieve complete suppression of specific antibody production in previously immunized animals5,6.

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Affiliations

  1. Yale School of Medicine, New Haven, Connecticut.

    • STANLEY ROSENBERG
    •  & PAUL CALABRESI

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https://doi.org/10.1038/1991101a0

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