Abstract
VARIOUS authors have suggested that the enzymatic equipment of neoplastic cells need not necessarily be immutable and that it may show variations as the result of a number of completely unknown influences. This communication describes a striking example of enzymatic dedifferentiation recently observed in a chemically induced squamous cell carcinoma subjected to serial transplantation by various routes. The logical consequence of such an observation is to make us aware of how fragile are the grounds accepted as bases for the procedures at present in use for screening compounds as anti-cancer agents.
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References
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THIERY, M., WILLIGHAGEN, R. Enzymatic Dedifferentiation of Neoplastic Cells. Nature 197, 1312–1313 (1963). https://doi.org/10.1038/1971312a0
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DOI: https://doi.org/10.1038/1971312a0
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