Letter | Published:

Glucose-6-Phosphate Dehydrogenase Deficient Mutant in Human Cell Culture

Naturevolume 193pages602603 (1962) | Download Citation

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Abstract

THE examination of known human genetic differences in cell culture is a prerequisite to the establishment of a somatic cell genetics of man. The recent paper on the inability of cell cultures from galactosæmic subjects to utilize galactose is the first report of the maintenance of a genetically determined metabolic difference in cell culture1. In this communication we wish to report the results of work on glucose-6-phosphate dehydrogenase activities in cell cultures from a subject with a genetically determined deficiency of glucose-6-phosphate dehydrogenase activity and from a series of normal subjects.

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References

  1. 1

    Krooth, R. S., and Weinberg, A. N., Biochem. and Biophys. Res. Comm., 3, 518 (1960).

  2. 2

    Edwards, J. H., Lancet, i, 496 (1960).

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Author notes

  1. STANLEY M. GARTLER: Senior Public Health Service Research Fellow.

Affiliations

  1. Departments of Medicine and Genetics, University of Washington, Seattle, and Istituto de Genetica Medica, Della Universita, Torino, Italy

    • STANLEY M. GARTLER
    • , ENRICO GANDINI
    •  & RUGGERO CEPPELLINI

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https://doi.org/10.1038/193602a0

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