Letter | Published:

Intracellular Response to an Iso-immune Reaction at the Surface of Ascites Tumour Cells

Naturevolume 192page1302 (1961) | Download Citation



THE cytotoxic effect on mouse ascites tumour cells treated in vitro with various antibodies has been shown to require the presence of complement1,2. In the absence of complement the cells appear to be normal when viewed by phase contrast microscopy3; they retain their capacity to exclude trypan blue2 and to metabolize glucose4. The only changes which have been reported are slight alterations in the fine structure of the cell surface, which were thought to favour agglutination by rabbit antibody directed against ascites cells3.

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    Wissler, R. W., and Flax, M. H., Ann. N.Y. Acad. Sci., 69, 773 (1957).

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    Gorer, P. A., and O'Gorman, P., Transplantation Bull., 3, 142 (1956).

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    Goldberg, B., and Green, H., J. Exp. Med., 109, 505 (1959).

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    Bickis, I. J., Quastel, J. H., and Vas, S. I., Cancer Res., 19, 602 (1959).

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    Gorer, P. A., Adv. Cancer Res., 4, 149 (1956).

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    Snell, G. D., J. Genet., 49, 87 (1948).

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    Bitensky, L., Quart. J. Micro. Sci. (in the press).

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    Baker, J. R., Quart. J. Micro. Sci., 87, 441 (1946).

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  1. Medical Research Council Rheumatism Research Unit, Canadian Red Cross Memorial Hospital, Taplow, Maidenhead, Berks

    • D. C. DUMONDE
  2. Department of Pathology, Royal College of Surgeons, Lincoln's Inn Fields, London, W.C.2

    • , G. J. CUNNINGHAM
    •  & J. CHAYEN


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