Letter | Published:

Stimulation of Uptake of Calcium-45 in the Adrenal Gland by Acetylcholine

Naturevolume 192page1299 (1961) | Download Citation



RECENTLY, Douglas and Rubin1 have suggested that acetylcholine, the physiological transmitter of sympathetic nerve effects at the adrenal medulla, evokes catecholamine secretion by causing calcium ions to penetrate the medullary cells. Our experiments with calcium-45 have now provided further evidence consonant with this idea.

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  1. 1

    Douglas, W. W., and Rubin, R. P., J. Physiol., 159, 24 P (1961); Biochem. Pharmacol., 8, 20 (1961). Douglas, W. W., and Rubin, R. P., J. Physiol., 159, 40 (1961).

  2. 2

    Harris, E. J., Transport and Accumulation in Biological Systems, second ed. (Butterworths, London; Academic Press, New York, 1960).

  3. 3

    Shanes, A. M., J. Cell. Comp. Physiol., 57, 193 (1960).

  4. 4

    Rosenfeld, G., Amer. J. Physiol., 183, 272 (1955).

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  1. Department of Pharmacology, Albert Einstein College of Medicine, Eastchester Road and Morris Park Avenue, New York, 61

    • W. W. DOUGLAS
    •  & A. M. POISNER


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