Abstract
THE property of water-insoluble amphipathic molecules to alter the electrokinetic charge of lipids has been exploited by Bangham and Dawson1 in elucidating the charge requirements of certain enzyme/substrate interactions. Their results show clearly the interdependence of both sign—positive or negative— and magnitude of enzyme and substrate interaction in any particular ionic environment. Whereas variation of pH, uni- or di-valent ion concentrations may affect the charge on both enzyme and substrate simultaneously, the addition of a water-insoluble amphipathic molecule to the lipid ensured an alteration of the substrate exclusively.
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References
Bangham, A. D., and Dawson, R. M. C., Biochem. J., 72, 486 (1959).
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Bell, W. N., and Alton, H. G., Nature, 174, 880 (1954).
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BANGHAM, A. A Correlation between Surface Charge and Coagulant Action of Phospholipids. Nature 192, 1197–1198 (1961). https://doi.org/10.1038/1921197a0
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DOI: https://doi.org/10.1038/1921197a0
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