Nucleolar Localization of Succinic Dehydrogenase in Normal Rat Hepatic Cells


SCRUTINY of the literature1–6 revealed that the oxidative enzyme, succinic dehydrogenase, is present in the mitochondria, occasionally in the cell membranes2, of all mammalian cells. The absence of this enzyme in the nuclei including the nucleoli is a very characteristic feature, except in bird erythrocytes, which according to Brachet7 may be due to the fact that bird erythrocytes have no mitochondria.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Marcuse, P. M., Lab. Invest., 6, No. 2, 137 (1957).

  2. 2

    Monis, B., Nachlas, M. M., and Seligman, A. M., Cancer Res., 12, No. 6, 1238 (1959).

  3. 3

    Nachlas, M. M., Tsou, K. C., De Souza, E., Cheng, C. S., and Seligman, A. M., J. Histochem. Cytochem., 5, No. 4, 427 (1957).

  4. 4

    Ogawa, K., and Zimmerman, H. M., J. Histochem. Cytochem., 7, No. 5, 342 (1959).

  5. 5

    Pearson, B., and Defendi, V., Cancer Res., 15, No. 9, 593 (1955).

  6. 6

    Wachstein, M., and Meisel, E., J. Biophys. Biochem. Cytol., 1, No. 6, 484 (1955).

  7. 7

    Brachet, J., Biochemical Cytology, 94 (Academic Press, Inc., New York, 1957).

  8. 8

    Friede, R., J. Histochem. Cytochem., 6, No. 5, 350 (1958).

  9. 9

    Inversen, O. H., Acta Path. et Microbiol. Scand., 47, fasc. 3, 216 (1959).

  10. 10

    Gurr, R., Methods of Analytical Histology and Histochemistry, 157 (Leonard Hill (Books), Ltd., London, 1958).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

DE, P., CHATTERJEE, R. & MITRA, S. Nucleolar Localization of Succinic Dehydrogenase in Normal Rat Hepatic Cells. Nature 191, 925 (1961).

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.