As part of a programme involving the investigation of general laboratory methods for the preparation of fluoropyridines1, we wish to report the synthesis of 2,6-difluoropyridine. The only other recorded example of a pyridine containing more than one nuclear fluorine is pentafluoropyridine2,3, which was prepared by methods best suited for the synthesis of perfluoro-aromatic compounds.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Finger, G. C., and Starr, L. D., J. Amer. Chem. Soc., 81, 2674 (1959).

  2. 2

    Stacey, P. M., and Tatlow, J. C., Nature, 186, 231 (1960).

  3. 3

    Haszeldine, R. N., et al., Proc. Chem. Soc., 211 (1960).

  4. 4

    Roe, A., Cheek, P. H., and Hawkins, G. F., J. Amer. Chem. Soc., 71, 4152 (1949).

  5. 5

    Miller, W. K., Knight, S. B., and Roe, A., J. Amer. Chem. Soc., 72, 4765 (1950).

  6. 6

    Roe, A., and Hawkins, G. F., J. Amer. Chem. Soc., 69, 2443 (1947).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

FINGER, G., STARR, L. 2,6-Difluoropyridine. Nature 191, 595 (1961). https://doi.org/10.1038/191595a0

Download citation

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.