Letter | Published:

Antibodies to Trophoblasts during the Post-Partum Period

Naturevolume 191pages510511 (1961) | Download Citation

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Abstract

RECENT investigation of homograft tolerance has stimulated speculation about the immunological relationship between mother and fœtus during pregnancy1,2. Since the fœtus with its placenta is genetically different from the maternal host, it can be looked upon as a homograft tolerated by the mother for nine months. Fundamental to the support of such a concept is the demonstration of an immune response by the mother to her products of conception at some time during or after pregnancy. In human beings, the syncytiotrophoblasts are the fœtal cells in direct contact with the maternal bloodstream. They invade the bloodstream and disappear1. It would seem, therefore, that an immune response by the mother would most likely be directed towards tropho-blasts. Although experimental homograft immunity is mediated primarily through a cellular response by the host3, the direct contact between trophoblasts and maternal blood might stimulate a humoral response as well. The large mass of trophoblastic tissue in the placenta could absorb circulating antibody effectively. This might explain previous reports of failure to detect antibodies to placenta during pregnancy4,5. After delivery of the fœtus and placenta, the absence of this absorptive surface might allow any anti-trophoblastic antibody to remain in the bloodstream, where it could be detected by appropriate methods.

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References

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    Douglas, G. W., Thomas, L., Carr, M., Cullen, N. M., and Morris, R., Amer. J. Obstet. and Gynec., 78, 960 (1959).

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    Hildeman, W. H., and Medawar, P. B., Immunology, 2, 44 (1959).

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    Thornes, D. R., thesis, University of Dublin (1958).

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    Olivelli, F., and Ruggieri, P., Minerva Gin Tor, 10, 953 (1958).

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Author notes

  1. J. F. HULKA: Josiah Macy, Foundation Fellow.

Affiliations

  1. Department of Microbiology and the Department of Obstetrics and Gynæcology, Columbia University College of Physicians and Surgeons, New York, 32

    • J. F. HULKA
    • , K. C. HSU
    •  & S. M. BEISER

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https://doi.org/10.1038/191510a0

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