Letter | Published:

Mast Cells in Photosensitivity Reactions

Naturevolume 191pages9091 (1961) | Download Citation



IN recent work1 it was found that cells obtained by washing out the rat's peritoneal cavity with saline could be rendered photosensitive. Exposure to light for a period too brief to affect leucocytes and serosal cells caused the granules of sensitized mast cells to lose their basophilic staining properties, after which they became refractory to the action of the histamine-releaser, compound 48/80. Mast cells reacted in this way even after being separated from the other cells by differential centrifugation.

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  1. 1

    McGovern, V. J., A.M.A. Arch. Derm., 83, 94 (1961).

  2. 2

    Archer, G. T., Nature, 182, 726 (1958).

  3. 3

    Lowry, O. H., Graham, H. T., Harris, I. B., Priebat, M. K., Marks, A. R., and Bregman, R. V., J. Pharm. Exp. Ther., 112, 116 (1954).

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  1. Fairfax Institute of Pathology, Royal Prince Alfred Hospital, Camperdown, New South Wales

    • V. J. McGOVERN


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