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Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide

Nature volume 190, pages 532–533 (1961)Cite this article

Abstract

ALIVISATOS et al. 1,2 reported the formation of histamine dinucleotide, that is, the pyrophosphate of histamine 5′-ribotide and of 5′-adenylic acid, from diphosphopyridine nucleotide (DPN) and histamine, using a soluble, purified preparation of diphosphopyridine nucleotidase3 (DPNase) from bovine spleen. It has been shown that nieotinamide4,5 inhibits the release of histamine by antigen from the lung tissue of a sensitized guinea pig. Nieotinamide is a known inhibitor of DPNase and nieotinamide ribosidase6. These facts suggest the possibility that part of the histamine released during the antigen–antibody reaction is formed from histamine dinucleotide.

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References

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Authors and Affiliations

  1. Department of Pharmacology, Okayama University Medical School, Okayama, Japan

    SAUBRO MURAOKA, MIE INOUE & HIDEMASA YAMASAKI

Authors
  1. SAUBRO MURAOKA
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  2. MIE INOUE
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  3. HIDEMASA YAMASAKI
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MURAOKA, S., INOUE, M. & YAMASAKI, H. Enzymatic Formation of Histamine Ribotide from Histamine Dinucleotide. Nature 190, 532–533 (1961). https://doi.org/10.1038/190532a0

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