Abstract
HÆMOGLOBIN E- thalassæmia disease represents a double heterozygous state with reference to genes for hæmoglobin E and thalassæmia. Studies on glutathione stability which have recently provided valuable information regarding the cause of hæmolysis as it occurs in drug-induced hæmolytic anæmia and in hereditary non-spherocytic hæmolytic anæmia have not so far been done in hæmoglobin E – thalassæmia disease. In the present communication, 20 cases of hæmoglobin E – thalassæmia disease were investigated with reference to the behaviour of their erythrocytically reduced glutathione-level when incubated in vitro with acetylphenylhydrazine. The relevant features of these 20 cases are given in Table 1.
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References
Beutler, E., J. Lab. Clin. Med., 49, 84 (1957).
Szeinberg, A., Sheba, Ch., and Adam, A., Blood, 13, 1043 (1958).
Beutler, E., Blood, 14, 103 (1959).
Kimbro, E. L., Bull. Johns Hopkins Hosp., 101, 118 (1957).
Zinkham, W. H., and Childs, B., J. Clin. Invest., 36, 938 (1957).
Walker, D. G., and Brown, J. E., Nature, 184, 1325 (1959).
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SWARUP, S., GHOSH, S. & CHATTERJEA, J. Glutathione Stability Test in Hæmoglobin E–Thalassæmia Disease. Nature 188, 153 (1960). https://doi.org/10.1038/188153a0
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DOI: https://doi.org/10.1038/188153a0
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