Abstract
THE pharmacology of plant-growth regulator acids has been little studied ; nevertheless, these substances which react in minute traces in green plants possess intense biological activity. We have prepared various esters of these acids with the intention, of studying their action on the central nervous system. Dimethylaminoethanol was chosen as the agent of esterification because Pfeiffer et al. 1 had demonstrated that this amino-alcohol has stimulating effects. We have synthesized the dimethylaminoethylic esters of the following acids : phenoxyacotic acid and some of its derivatives substituted on the aromatic nucleus (4-chloro-, 4-fluoro-, 2,4-dichloro-, 2-methyl-4-chloro-compounds), naphthalenic acid, α- and β-naphthoxyacetic acid, 3-indolylacetic acid, phenylpropionic acid.
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References
Pfeiffer, C. C., Jenney, E. H., Gallagher, W., Smith, R. P., Bevan, jun., W., Killam, K. F., Killam, E. K., and Blackmore, W., Science, 126, 610 (1957).
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Minz, B., Thuillier, J., and Nakajima, H., C.R. Soc. Biol., Paris, 153, 744 (1959).
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THUILLIER, J., THUILLIER, G. & RUMPF, P. Evidence of a Specific Action on the Central Nervous System by the Esters of Some Plant Growth Regulator Acids. Nature 188, 152–153 (1960). https://doi.org/10.1038/188152a0
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DOI: https://doi.org/10.1038/188152a0
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