Abstract
Schwartz and Dameshek1,2 have reported the apparent production of immunological tolerance in rabbits by the administration of a purine analogue, 6-mercaptopurine. Rabbits receiving concomitantly human serum albumin and 6-mercaptopurine failed to develop an immune response to the protein antigen, and weeks later, when antigen alone was administered, the animals remained tolerant. In an effort to confirm this finding and to explore the possible effects of 6-mercaptopurine on homografts in rabbits, two groups of rabbits received injections of ovalbumin in Freund's adjuvant and were grafted with skin from a common donor rabbit. One of these groups received 6-mercaptopurine in the maximum dose employed by Schwartz and Dameshek, the other group serving as controls. The 6-mercaptopurine did not produce immunological tolerance for ovalbumin nor did it result in successful homografts.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Schwartz, R., and Dameshek, W., Nature, 183, 1682 (1959).
Schwartz, R., Eisner, A., and Dameshek, W., J. Clin. Invest., 38, 1394 (1959).
Kabat, E. A., and Mayer, M., “Experimental Immunochemistry” (C. C. Thomas, Springfield, 1948).
Ovary, Z., Internat. Arch. Allergy and App. Immunol., 3, 162, 293 (1952).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ROBINSON, J., CHRISTIAN, C. 6-Mercaptopurine in Immunological Responsiveness. Nature 187, 796–797 (1960). https://doi.org/10.1038/187796a0
Issue Date:
DOI: https://doi.org/10.1038/187796a0
This article is cited by
-
Immunologic tolerance produced in adult animals by combined injection of cyclophosphamide and antigen (sheep's erythrocytes)
Bulletin of Experimental Biology and Medicine (1969)
-
Inhibition of precipitin formation in the guinea-pig with cyclophosphamide
Experientia (1963)
-
Effect of Cyclophosphoramide, 6-Mercaptopurine, Actinomycin D and Vincaleukoblastine on the Acquisition of Delayed Hypersensitivity (DNCB Contact Dermatitis) in the Guinea-Pig11From the Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia 4, Pennsylvania.This study was supported in part by U.S.P.H.S. Training Grant 2 G-62.This investigation was carried out during the tenure of a postdoctoral fellowship, held by Dr. Maibach, from the Division of General Medical Sciences, United States Public Health Service.Cyclophosphoramide (Cytoxan®) was supplied by Paul A. Walter, M.D., Mead Johnson Laboratories, Evansville 21, Indiana; 6-mercaptopurine by Donald S. Searle, M.D., Burroughs Wellcome & Co., Tuckahoe, N.Y.; vincaleukoblastine by J. A. Armstrong, M.D., Eli Lilly and Co., Indianapolis 6, Indiana; and Actinomycin D by Elmer Alpert, M.D., Merck Sharp and Dohme, West Point, Pa.Presented at the Twenty-second Annual Meeting of The Society for Investigative Dermatology, Inc., New York, N.Y., June 28, 1961.
Journal of Investigative Dermatology (1961)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.