Abstract
WE wish to report the partial structures of PA114B-1 and PA114B-3, members of the PA114 group of synergistic antibiotics obtained from a strain of Streptomyces 1. Other reported synergistic antibiotic groups include streptogramin2, staphylomycin3, antibiotic E1294, and mikamycin5. Bioautographic comparisons by us6 and others4,5 have indicated identities and close similarities between various members of the groups. Table 1 summarizes these comparisons and embodies a proposed universal system of designations.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Celmer, W. D., and Sobin, B. A., “Antibiotics Annual 1955–1956”, 437 (Medical Encyclopedia, Inc., New York).
Charney, J., Fisher, W. P., Curran, C., Machlowitz, R. A., and Tytell, A. A., Antibiotics and Chemother., 3, 1283 (1953).
Vanderhaeghe, H., Van Dijck, P., Parmentier, G., and De Somer, P., Antibiotics and Chemother., 7, 606 (1957).
Ball, S., Boothroyd, K. A., Lees, K. A., Raper, A. H., and Smith, E. L., Biochem. J., 68, 24 (1958).
Arai, M., Okabe, K., Yonehara, H., and Umezawa, H., J. Antibiotics, 11, A, 21 (1958).
Hobbs, D. C., and Celmer, W. D., Fed. Proc., 18, 246 (1959).
Vanderhaeghe, H., and Parmentier, G., Bull. Soc. Chim. Belg., 68, 716 (1959).
Sheehan, J. C., Zachau, H. G., and Lawson, W. B., J. Amer. Chem. Soc, 80, 3349 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HOBBS, D., CELMER, W. Structure of the Antibiotics PA114B-1 and PA114B-3. Nature 187, 598–599 (1960). https://doi.org/10.1038/187598a0
Issue Date:
DOI: https://doi.org/10.1038/187598a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.