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Structure of the Antibiotics PA114B-1 and PA114B-3

Abstract

WE wish to report the partial structures of PA114B-1 and PA114B-3, members of the PA114 group of synergistic antibiotics obtained from a strain of Streptomyces 1. Other reported synergistic antibiotic groups include streptogramin2, staphylomycin3, antibiotic E1294, and mikamycin5. Bioautographic comparisons by us6 and others4,5 have indicated identities and close similarities between various members of the groups. Table 1 summarizes these comparisons and embodies a proposed universal system of designations.

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References

  1. Celmer, W. D., and Sobin, B. A., “Antibiotics Annual 1955–1956”, 437 (Medical Encyclopedia, Inc., New York).

  2. Charney, J., Fisher, W. P., Curran, C., Machlowitz, R. A., and Tytell, A. A., Antibiotics and Chemother., 3, 1283 (1953).

    CAS  Google Scholar 

  3. Vanderhaeghe, H., Van Dijck, P., Parmentier, G., and De Somer, P., Antibiotics and Chemother., 7, 606 (1957).

    CAS  Google Scholar 

  4. Ball, S., Boothroyd, K. A., Lees, K. A., Raper, A. H., and Smith, E. L., Biochem. J., 68, 24 (1958).

    Google Scholar 

  5. Arai, M., Okabe, K., Yonehara, H., and Umezawa, H., J. Antibiotics, 11, A, 21 (1958).

    CAS  Google Scholar 

  6. Hobbs, D. C., and Celmer, W. D., Fed. Proc., 18, 246 (1959).

    Google Scholar 

  7. Vanderhaeghe, H., and Parmentier, G., Bull. Soc. Chim. Belg., 68, 716 (1959).

    CAS  Google Scholar 

  8. Sheehan, J. C., Zachau, H. G., and Lawson, W. B., J. Amer. Chem. Soc, 80, 3349 (1958).

    Article  CAS  Google Scholar 

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HOBBS, D., CELMER, W. Structure of the Antibiotics PA114B-1 and PA114B-3. Nature 187, 598–599 (1960). https://doi.org/10.1038/187598a0

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