Abstract
PREVIOUS work with induced immunological tolerance of skin grafts presented evidence of a strict specificity of acquired tolerance. The ‘non-specific’ tolerance chould be induced in ducks by injecting them with a mixture of bone marrow and spleen cells from 60 pooled donors1. This finding, as well as other observations of ‘non-specific’ tolerance2 can be explained by the antigenic overlapping between individuals genetically related to a certain extent. However, it was shown that, when heterografts were tolerated, tolerance of heterografts from other individuals of the same species could be also obtained. In one instance, tolerance of a turkey homograft3 was found in a turkey which tolerated two chicken hetorografts.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hašek, M., and Hašková, V., presented at the Conference on the Biological Basis of Tissue Transplantation, Prague, 1957, see Transpl. Bull., 5, 69 (1958).
Terasaki, P. J., Cannon, J. A., and Longmire, W. P., J. Immunol., 81, 246 (1958). Billingham, R. E., and Brent, L., Phil. Trans. Roy. Soc., B, 242, 439 (1959).
Hašek, M., Hraba, T., and Hort, J., Nature, 183, 1199 (1959).
Brent, L., Brown, J. B., and Medawar, P. B., “Biological Problems of Grafting”, 64 (Liège, 1959). Stetson, C. A., ibid., 79.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HAŠEK, M., HORT, J. Non-specific Tolerance of Graft and the Dissociation of Two Types of Immunity. Nature 186, 985–986 (1960). https://doi.org/10.1038/186985a0
Issue Date:
DOI: https://doi.org/10.1038/186985a0
This article is cited by
-
Active mechanisms of immunological tolerance
Survey of Immunologic Research (1984)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
