Abstract
IT was found that the condensation reaction of ethylenediamine with adrenaline gave the main condensation product of noradrenaline as one of its by-products1. From this result, it was supposed that the side-chain of these two catechol amines could be destroyed during the condensation reaction and that the structure of the main condensation product of noradrenaline might be simpler than that of adrenaline. To investigate the structure of the main condensation product of noradrenaline, we examined further the condensation products of ethylenediamine with catechol and its derivatives which have a simpler structure than adrenaline or noradrenaline. For this purpose, 3,4-dihydroxymandelic acid (kindly provided by Dr. M. D. Armstrong) and catechol were used.
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YAGI, K., NAGATSU, T. & NAGATSU, I. Condensation Product of Ethylenediamine with Noradrenaline or 3,4-Dihydroxymandelic Acid. Nature 186, 310–311 (1960). https://doi.org/10.1038/186310a0
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DOI: https://doi.org/10.1038/186310a0
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