Abstract
POLYOMA virus can induce multiple tumours in mice1, hamsters2 and rats3. To obtain tumours in a high percentage of animals, the animals must be inoculated when newly born or at a very early age. Such a requirement is not unusual for tumour-inducing viruses—the Gross leukæmia virus, for example4. The relationship of susceptibility to early age suggests that immunological immaturity in the host is a prerequisite for tumour induction by the virus. In this communication, preliminary results of experiments are reported which indicate that the presence of adult lymphoid tissue may be an important factor in determining the appearance and progression of virus-induced tumours.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Stewart, S. E., Eddy, B. E., and Borgese, N., J. Nat. Cancer Inst., 20, 1223 (1958).
Eddy, B. E., Stewart, S. E., Young, R., and Mider, G. B., J. Nat. Cancer Inst., 20, 747 (1958).
Eddy, B. E., Stewart, S. E., Stanton, M. F., and Marcotte, J. M., J. Nat. Cancer Inst., 22, 161 (1959).
Gross, L., Cancer Res., 18, 371 (1958).
Defendi, V. (unpublished results).
Clark, S. L., J. Biophys. Biochem. Cytol., 5, 41 (1959).
Pietra, G., Spencer, K., and Shubik, P., Nature, 183, 1689 (1959).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
DEFENDI, V., KOPROWSKI, H. Influence of Adult Lymphoid Tissues on Polyoma-induced Tumours. Nature 184, 1579–1580 (1959). https://doi.org/10.1038/1841579a0
Issue Date:
DOI: https://doi.org/10.1038/1841579a0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.