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Incidence of the Erythrocytic Defect associated with Drug-Sensitivity among Oriental Subjects

Nature volume 183, pages 684–685 (1959)Cite this article

Abstract

IN the past few years a new type of metabolic lesion of the red cell has been elucidated. It was found that sensitivity to the hæmolytic action of the 8-aminoquinoline primaquine and many other compounds was due to an intrinsic defect of the red cell1. This defect can be demonstrated in vitro by: (1) incubating the red cells with a solution of acetylphenylhydrazine and observing the pattern of Heinz body formation2, and (2) incubating the red cells with acetylphenylhydrazine or a number of other substances and measuring the level of reduced glutathione after an incubation period of 2 hr. (the glutathione stability test)3, or (3) measuring the activity of the enzyme glucose-6-phosphate dehydrogenase in the red cells4.

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Authors and Affiliations

  1. Argonne Cancer Research Hospital*,

    ERNEST BEUTLER, MARY K. Y. YEH & THOMAS NECHELES

  2. the Department of Medicine, University of Chicago, Chicago, 37

    ERNEST BEUTLER, MARY K. Y. YEH & THOMAS NECHELES

Authors
  1. ERNEST BEUTLER
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  2. MARY K. Y. YEH
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  3. THOMAS NECHELES
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BEUTLER, E., YEH, M. & NECHELES, T. Incidence of the Erythrocytic Defect associated with Drug-Sensitivity among Oriental Subjects. Nature 183, 684–685 (1959). https://doi.org/10.1038/183684b0

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