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Metabolism of Sulphobromophthalein

Nature volume 183, pages 469–470 (1959)Cite this article

Abstract

DESPITE the great sensitivity and widespread use of sulphobromophthalein (BSP) retention as an index of liver function, little is known of the actual function(s) involved in the hepatic uptake and excretion of the dye. Presumably, sulphobromophthalein is bound to proteins in the serum and is thus conveyed to the liver, where the pigment–protein complex is broken. On release it is excreted into the bile as the free dye1. We have found, however, that pigments of sulphobromophthalein appearing in the bile and other biological fluids are chromatographically different from the parent compound2, suggesting that a chemical modification is involved in the clearance of sulphobromophthalein by the liver.

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Authors and Affiliations

  1. Department of Medicine, University of California School of Medicine,

    G. M. GRODSKY, J. V. CARBONE & R. FANSKA

  2. the Gastrointestinal Clinic (University of California Service), San Francisco Hospital, San Francisco

    G. M. GRODSKY, J. V. CARBONE & R. FANSKA

Authors
  1. G. M. GRODSKY
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  2. J. V. CARBONE
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  3. R. FANSKA
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GRODSKY, G., CARBONE, J. & FANSKA, R. Metabolism of Sulphobromophthalein. Nature 183, 469–470 (1959). https://doi.org/10.1038/183469a0

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