Abstract
IN previous studies1 we demonstrated that the intact rat was capable of demethylating chlorpromazine-(N-methyl)-14C when production of carbon dioxide was used as an index of demethylation. The liver seemed to be the likely tissue responsible for these findings, since Mueller and Miller2 had found that homogenates of rat liver were capable of demethylation. La Du et al. 3 later developed a simpler system for demethylation using homogenates of rabbit, rat and guinea pig livers. However, using the system of La Du et al., Salzman and Brodie4 reported that no demethylation of chlorpromazine occurred with rabbit liver. Since we had observed the in vivo demethylation of chlorpromazine, we decided to study its in vitro demethylation by fortified homogenates of rabbit and rat liver prepared according to these procedures2,3.
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References
Ross, jun., J. J., Young, R. L., and Maass, A. R., Science, 128, 1279 (1958).
Mueller, G. C., and Miller, J. A., J. Biol. Chem., 202, 579 (1953).
La Du, B. N., Gaudette, L., Trousef, N., and Brodie, B. B., J. Biol. Chem., 214, 741 (1955).
Salzman, N. P., and Brodie, B. B., J. Pharmacol. Exp. Therap., 118, 46 (1956).
Kamm, J. J., Gillette, J. R., and Brodie, B. B., Fed. Proc., 17, 382 (1958).
Cook, L., (unpublished work).
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YOUNG, R., Ross, J. & MAASS, A. Role of Liver in Metabolism of Chlorpromazine. Nature 183, 1396–1397 (1959). https://doi.org/10.1038/1831396a0
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DOI: https://doi.org/10.1038/1831396a0
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