Abstract
DUNNING et al. 1 demonstrated that bladder cancer due to 2-acetylaminofluorene was produced in almost all rats (strain Fisher 344) on a diet containing large quantities (1.4–4.3 per cent) of tryptophan. On the other hand, rats on a diet containing smaller amounts of tryptophan did not develop bladder cancer. We showed that the administration of 2-acetylaminofluorene inhibits 3-hydroxyanthranilic acid oxidase in rat hepatic tissue2, with consequent accumulation of the two carcinogenic o-aminophenolic compounds 3-hydroxyanthranilic acid and 3-hydroxy-kynurenine3. It seemed of interest to pursue these studies in order to elucidate the mechanism of this inhibition.
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QUAGLIARIELLO, E., AURICCHIO, S., RINALDI, E. et al. Effect of Diphosphopyridine Nucleotide on the Inhibition of Rat Liver 3-Hydroxy-anthranilic-Acid Oxidase by 2-Acetyl-aminofluorene and N-2-Fluorenyl-diacetamide. Nature 182, 1744 (1958). https://doi.org/10.1038/1821744a0
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DOI: https://doi.org/10.1038/1821744a0
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