Abstract
ALBERT1 has suggested that xanthopterin would be found in higher amounts in neoplastic tissues than in normal. In anticipation of confirming this by direct experiment, we have analysed for their pterin content, normal kidney tissue of the golden hamster and transplantable neoplasms in the golden hamster, derived from stilbœstrol-induced renal tumours2. No xanthopterin could be found. The largest amount of tissue used was 1 gm. of normal tissue and 8 gm. of neoplastic tissue, and the smallest amount of xanthopterin that could be detected by the paper chromatographic technique used was 0.l µgm.
Similar content being viewed by others
Article PDF
References
Albert, A., Biochem. J., 65, 124 (1957); 57, x (1954).
Horning, E. S., Z. Krebsforschung, 61, 1 (1956).
Koschara, W., Hoppe Seylers Z., 240, 127 (1936).
Wieland, H., and Liebig, R., Ann., 555, 146 (1944). Kalckar, H. M., Kjeldgaard, N. O., and Klenow, H., Biochim. Biophys. Acta, 5, 575 (1950).
Haddow, A. C., “Chemistry and Biology of Pteridines”, 101 (J. and A. Churchill, London, 1954).
Blair, J. A., Biochem. J. (in the press).
Kalckar, H. M., Floystrup, T., and Schou, M., Proc. 1st Internat. Congr. Biochem., 75 (1949). Floystrup, T., Schou, M., and Kalckar, H. M., Acta Chem. Scand., 3, 985 (1949).
Futterman, S., and Silverman, M., J. Biol. Chem., 224, 31 (1957).
Blakley, R. L., Biochem. J., 65, 331 (1957).
Slavik, K., Dvorakova, A., and Slavikova, V., Chem. listy, 51, 1536 (1957).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BLAIR, J. Metabolic Role of Xanthopterin. Nature 181, 996 (1958). https://doi.org/10.1038/181996a0
Issue Date:
DOI: https://doi.org/10.1038/181996a0
This article is cited by
-
Pterine als Wirkstoffe und Pigmente
Ergebnisse der Physiologie Biologischen Chemie und Experimentellen Pharmakologie (1965)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.