Effect of Creatine Phosphate Administration on the Cardiac Adenosine Triphosphate of Thyroxinized Rats

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Abstract

THE amounts of adenosine triphosphate, creatine phosphate and inorganic phosphorus in the heart of hyperthyroid animals are below normal. These amounts are restored to about the normal level by administration of adenosine triphosphate, whereas with cocarboxylase and organic phosphates restoration is incomplete1. Moreover, thyroxin intoxication reduces the creatine content of the skeletal muscle and the rate of creatine synthesis by liver2.

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References

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    Mascitelli-Coriandoli, E., and Boldrini, R., Nature, 179, 474 (1957).

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    Mascitelli-Coriandoli, E., and Boldrini, R., Nature, 179, 1196 (1957).

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    La Page, G. A., “Manometric Methods and Tissue Metabolism” (Burgess, Minneapolis, 1951).

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    Hawk, P. B., et al., “Practical Physiological Chemistry” (Blakiston, Philadelphia, 1949).

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    Kahan, J., Arch. Biochem. Biophys., 47, 408 (1953).

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ANGELUCCI, L., BOLDRINI, R. & MASCITELLI-CORIANDOLI, E. Effect of Creatine Phosphate Administration on the Cardiac Adenosine Triphosphate of Thyroxinized Rats. Nature 181, 419–420 (1958) doi:10.1038/181419b0

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