Abstract
IMMATURE rabbit erythrocytes (reticulocytes) have been found in several laboratories to be involved in the formation of hæmoglobin. This process was either measured directly by determining the increase in hæmoglobin1 or through the incorporation of amino-acids into globin, glycine or iron into hæm. Following the kinetic evidence that the microsomes of intact reticulocytes participate in globin formation2, we have attempted to study the steps of this synthesis with cell-free preparations. In this communication, we describe a role of the microsomes in what may be the final step in hæmoglobin formation—the insertion of iron.
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RABINOVITZ, M., OLSON, M. Participation of Reticulocyte Microsomes in the Incorporation of Iron into Hæmoglobin. Nature 181, 1665–1666 (1958). https://doi.org/10.1038/1811665a0
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DOI: https://doi.org/10.1038/1811665a0
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