Letter | Published:

Free-Radicals produced in Cigarette Smoke

Abstract

IN attempts to determine a unifying principle of action for the many and varied carcinogenic agents, many workers have assigned an intermediary role to free radicals. The action of ionizing radiation and radiomimetic agents in this respect has been discussed by Brues and Barron1. It is stated that many, if not all, carcinogens are compounds capable of forming free radicals which may be stabilized as ions2. Oppenheimer et al. 3 discussed their possible role in the production of tumours in rodents by implanted films of various high polymers, and suggested, as a requirement for tumour production, the presence of foreign free radicals in a specific area for an extended period.

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References

  1. 1

    Brues, A. M., and Barron, E. S. G., “Ann. Rev. Biochem.”, 20, 350 (1951).

  2. 2

    Oppenheimer, B. S., Oppenheimer, E. T., Stout, A. P., Danishefsky, I., and Eirch, F. R., Science, 118, 783 (1953).

  3. 3

    Oppenheimer, B. S., Oppenheimer, E. T., Stout, A. P., Danishefsky, I., and Eirch, F. R., Cancer Research, 15, 333 (1955).

  4. 4

    Ingram, D. J. E., “Spectroscopy at Radio and Microwave Frequencies”, 96 (Butterworths, London, 1955).

  5. 5

    Ingram, D. J. E., and Tapley, J. G., Chem. and Indust., 568 (1955).

  6. 6

    Steiner, P. E., Cancer Research, 14, 103 (1954).

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