Abstract
THE property of 11-β-hydroxyprogesterone in preventing œstrogen-induced fibroids or œstrogen-induced uterine growth is greatly enhanced1 by introduction of fluorine at C(9) (Fig. 1) ; the same applies to the antiluteinizing potency (unpublished work). The antiœstrogenic potencies of the halogenated 11-β-hydroxy compound are possibly even greater than those of progesterone.
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References
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LIPSCHUTZ, A., JADRIJEVIC, D., FIGUEROA, S. et al. Resistance of 9-α-Fluoro-11-β-Hydroxyprogesterone to Inactivation in the Liver of the Guinea Pig. Nature 180, 508–509 (1957). https://doi.org/10.1038/180508a0
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DOI: https://doi.org/10.1038/180508a0
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