Letter | Published:

Development of Multiple Cysts and of Hæmorrhagic Affections of Internal Organs in Albino Rats treated during the Embryonic or New-born Period with Rous Sarcoma Virus

Nature volume 180, pages 12991300 (07 December 1957) | Download Citation



IN contrast to other malignant animal tumours, such as the Ehrlich adenocarcinoma of mice, the Croker mice sarcoma or the Brown–Pierce rabbit epithelioma, which could be transplanted to the embryos of white rats in serial passages1, the tissue of the Rous chick sarcoma could only exceptionally be grown under such conditions. However, in many rats grown from embryos inoculated with minced tissue of the Rous sarcoma we have detected2 multiple cysts. The observations recorded here reveal that white rats are highly susceptible to the Rous sarcoma virus administered both during embryonic life and the first two days of postnatal life.

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  1. 1.

    , “Problems of Oncology” (“Voprosi oncologii”) (in the press, 1956).

  2. 2.

    , and , “Problems of Oncology” (“Voprosi oncologii”) (in the press).

  3. 3.

    , Yale J. Biol. and Med., 41, 77 (1940); 50, 555 (1950); Proc. Soc. Exp. Biol. and Med., 45, 367 (1940).

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  1. The L.A. Tarasevich State Control Institute of Sera and Vaccines, Moscow.



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