Abstract
AS part of a study of skin sensitization to penicillin and its derivatives, we have been investigating the behaviour of penicillamine (β,β′-dimethylcysteine). Since D-penicillamine proved capable of eliciting allergic skin responses1, it was expected that it would react with epidermal proteins2, possibly through cystine or cysteine residues. Accordingly, it was of interest to determine whether this sulphydryl compound reacts with cystine or cysteine. It was found that a reaction occurs readily with cystine with the formation of a mixed disulphide which is here designated penicillamine–cysteine.
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References
Eisen, H. N., Levine, B., and Tabachnick, M. (unpublished data).
Eisen, H. N., and Belman, S., J. Exp. Med., 98, 533 (1953).
Clark, H. T., J. Biol. Chem., 97, 233 (1932).
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TABACHNICK, M., EISEN, H. & LEVINE, B. A New Mixed Disulphide: Penicillamine–Cysteine. Nature 174, 701–702 (1954). https://doi.org/10.1038/174701b0
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DOI: https://doi.org/10.1038/174701b0
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