Abstract
THE presence of substance P in the central nervous system was first shown by Euler and Gaddum1. According to recent work on the distribution of this substance in the brain2,3, the largest amounts are found in the basal ganglia, the hypothalamus, the midbrain and the grey matter of the spinal cord. Nothing is known about the action and function of substance P in the nervous system. We have now observed tachypnœa and hyperpnœa produced by substance P injected into the third ventricle of the rabbit and the cat.
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Euler, U. S. v., and Gaddum, J. H., J. Physiol., 72, 74 (1931).
Amin, A. H., Crawford, T. B. B., and Gaddum, J. H., XIXth Int. Physiol. Cong. (1953). Kopera, H., and Lazarini, W., Arch. Exp. Path. Pharmakol., 219, 214 (1953).
Pernow, B., Acta Physiol. Scand, 29, Supp. 105, 1 (1953).
Euler, U. S. v., Acta Physiol. Scand., 4, 373 (1942).
Feldberg, W., and Sherwood, S. L., J. Physiol., 123, 148 (1954).
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EULER, U., PERNOW, B. Effects of Intraventricular Administration of Substance P. Nature 174, 184 (1954). https://doi.org/10.1038/174184a0
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DOI: https://doi.org/10.1038/174184a0
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