Abstract
IN the course of experiments dealing with correlations between structure and effect of cholinergic-blocking (antimuscarine, antinicotinic) actions1,2, it has been found that in the case of compounds with tropeine structure the influence exerted on the effects by different quaternary groups shows great variations. Quaternary derivatives of tropeines possessing local anæsthetic properties, for example, benzoyltropine (= benzoyl-anti-tropine)3, as well as benzoyl-ψ-tropine (= benzoyl-syn-tropine), have been prepared and studied5, special consideration being given to the correlations between stereo-structure and pharmacological effect. Antimuscarine, ganglionic-blocking, curare-like, as well as local anæsthetic actions have been investigated. The effects of the individual compounds are shown in the accompanying table.
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Gyermek, L., Acta Physiol. Hung., 2/3–4, 511 (1951).
Gyermek, L., and Nádor, K., Acta Physiol. Hung., 3/1, 183 (1952).
Fodor, G., Nature, 170, 278 (1952).
Gyermek, L., and Kisérletes, Orvostud, Arch. Int. Pharmacodyn. (in the press).
Gyermek, L., Acta Physiol. Hung. (in the press).
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GYERMEK, L. Quaternary Derivatives of Benzoyltropine and Benzoyl-ψ-tropine with Anticholinergic and Local Anæsthetic Properties. Nature 171, 788 (1953). https://doi.org/10.1038/171788a0
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DOI: https://doi.org/10.1038/171788a0
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