Abstract
SUBSTANCE P is a biologically active polypeptide found in extracts of brain and intestine1,2. It causes a transient fall of the blood pressure and stimulation of smooth muscle even in the presence of atropine and antihistamine drugs. Purified preparations exert biological effects even in concentrations of 1 µgm. per ml. The present communication deals with its distribution in the nervous system.
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References
Euler, U. S. v., and Gaddum, J. H., J. Physiol., 72, 74 (1931).
Euler, U. S. v., Arch. Exp. Path. Pharmak., 181, 181 (1936).
Euler, U. S. v., Acta Physiol. Scand., 4, 373 (1942).
MacIntosh, F. C., J. Physiol., 99, 436 (1941).
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PERNOW, B. Distribution of Substance P in the Central and Peripheral Nervous System. Nature 171, 746 (1953). https://doi.org/10.1038/171746a0
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DOI: https://doi.org/10.1038/171746a0
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