Abstract
WE have been seeking the mechanism to explain our observation that one of the substances which is contained in broth and is able to decrease the inhibitory effect of isonicotinic acid hydrazide on the growth of E. coli can, to some extent, be replaced by pyridoxine1. In further experiments, we have found that isonicotinic acid hydrazide considerably inhibits the formation by E. coli of indole, and that the activity of a suspension of E. coli treated with isonicotinic hydrazide recovers when the cells are in contact with pyridoxine.
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Yoneda, M., 63rd Nagoya Medical Association, May 18, 1952. Yoneda, M., Kato, N., Okajima, M., Asano, N., Takatori, T., Shiraya, J., and Kitaori, M., Curr. Med., 2, No. 3 (1952) (in Jap.). Ata, S., Yoneda, M., Nagata, I., Kato, N., Okajima, M., Iso, T., and Shiraya, J., Curr. Med., 2, No. 3 (1952) (in Jap.).
Wood, W. A., Gunsalus, I. C., and Umbreit, W. W., J. Biol. Chem., 170, 313 (1947).
Yoneda, M., and Asano, N., Science (in the press).
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YONEDA, M., KATO, N. & OKAJIMA, M. Competitive Action of Isonicotinic Acid Hydrazide and Vitamin B6 in the Formation of Indole by E. coli. Nature 170, 803 (1952). https://doi.org/10.1038/170803a0
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DOI: https://doi.org/10.1038/170803a0
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