Abstract
Yanif and Avi-Dor1 have reported that very low concentrations of methylene blue (0.5 µgm./ml.) inhibit the growth in vitro of Bact. tularense, but that this dye had no effect in vivo; “doses of 0.5 gm. [0.5 mgm.?] each, applied intraperitoneally for three successive days, did not protect mice infected even with low doses (1–10 LD50) of the bacterium”.
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References
Yanif, H., and Avi-Dor, J., Nature, 169, 201 (1952).
Guttmann, P., and Ehrlich, P., Berl. klin. Wschr., 28, 953 (1891).
Ehrlich, P., and Hata, S., “The Experimental Chemotherapy of the Spirilloses” (1911).
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LAWRENCE, J. Toxicity of Methylene Blue to Leptospira icterohæmorrhagiæ. Nature 170, 327–328 (1952). https://doi.org/10.1038/170327c0
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DOI: https://doi.org/10.1038/170327c0
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