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Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy

Bone Marrow Transplantation volume 25, pages 205–207 (2000)Cite this article

Abstract

A syndrome akin to graft-versus-host disease in the recipient of syngeneic stem cells is hitherto described as being milder, self-limiting and confined to the skin. It is enhanced by prior cyclosporin A therapy. We describe here a recipient of a syngeneic marrow transplant who did not receive priming with cyclosporin A and yet developed severe and progressive graft-versus-host disease which necessitated and responded to high-dose immunosuppressive therapy. We believe that this is because the conditioning regimen in stem cell transplant acts to reset the immune system enabling it to recognise ‘self’ antigens. Bone Marrow Transplantation (2000) 25, 205–207.

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  1. Department of Haematology, Singapore General Hospital, Singapore

    WYK Hwang, YT Goh, CH Tan, GF How & HCP Tan

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  1. WYK Hwang
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  2. YT Goh
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  3. CH Tan
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  4. GF How
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  5. HCP Tan
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Hwang, W., Goh, Y., Tan, C. et al. Severe acute graft-versus-host disease occurring after syngeneic BMT for AML in a patient not given prior cyclosporin A therapy. Bone Marrow Transplant 25, 205–207 (2000). https://doi.org/10.1038/sj.bmt.1702115

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