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Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation

Bone Marrow Transplantation volume 23, pages 959–962 (1999)Cite this article

Abstract

A 54-year-old woman with a myelodysplastic syndrome treated with high-dose chemotherapy and an allogenic bone marrow transplant developed acute cortical blindness while receiving tacrolimus (FK506). MRI showed white matter abnormalities. After discontinuation of FK506, the patient’s vision returned within 8 days. FK506 neurotoxicity is similar to cyclosporine neurotoxicity and can occur in allogenic bone marrow transplant patients treated with FK506.

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Authors and Affiliations

  1. Department of Neurology, Creighton University School of Medicine, Omaha, NE, USA

    RE Steg

  2. Department of Internal Medicine, Section of Hematology and Oncology, University of Nebraska Medical Center, Omaha, NE, USA

    A Kessinger

  3. Department of Internal Medicine, Section of Neurology, University of Nebraska Medical Center, Omaha, NE, USA

    ZK Wszolek

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  1. RE Steg
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  2. A Kessinger
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  3. ZK Wszolek
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Steg, R., Kessinger, A. & Wszolek, Z. Cortical blindness and seizures in a patient receiving FK506 after bone marrow transplantation. Bone Marrow Transplant 23, 959–962 (1999). https://doi.org/10.1038/sj.bmt.1701732

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  • DOI: https://doi.org/10.1038/sj.bmt.1701732

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